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Symptoms: Excessive peripheral vasodilation and possibly a reflex tachycardia.
Treatment: If massive overdose should occur, institute active cardiac and respiratory monitoring. Frequent blood measurements are essential. Initiate cardiovascular support including elevation of the extremities and judicious fluid administration should hypotension occur. If hypotension remains unresponsive to these conservative measures, administration of vasopressors should be considered with attention to circulating volume and urine output. Calcium gluconate IV may help to reverse the effects of calcium entry blockade. As amlodipine is highly protein bound, hemodialysis is not likely to be of benefit.
